DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Background & Aims Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) both exhibit
notable cancer stem cell (CSC) features. Moreover, the development of both diseases is …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …

The epigenome, including DNA methylation, is stably propagated during mitotic division.
However, single-cell clonal expansion produces heterogeneous methylomes, thus raising …

Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …

In mammals, telomere protection is mediated by the essential protein TRF2, which binds
chromosome ends and ensures genome integrity,. TRF2 depletion results in end-to-end …

Minority subpopulations within embryonic stem cell cultures display an expanded
developmental potential similar to that of early embryo blastomeres or the early inner cell …

The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress.
However, its role in regulating stem cell fate remains unclear. Here, we present evidence …