Vav1: a key signal transducer downstream of the TCR
VLJ Tybulewicz, L Ardouin, A Prisco… - Immunological …, 2003 - Wiley Online Library
Vav1 is a 95‐kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine
phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …
phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …
A review of actin binding proteins: new perspectives
R Uribe, D Jay - Molecular biology reports, 2009 - Springer
Actin binding proteins (ABPs) have been considered components of the cytoskeleton, which
gives structure and allows mobility of the cell. The complex dynamic properties of the actin …
gives structure and allows mobility of the cell. The complex dynamic properties of the actin …
Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185HER2 and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
LYW Bourguignon, H Zhu, B Zhou, F Diedrich… - Journal of Biological …, 2001 - ASBMB
In this study we initially examined the interaction between CD44v3 (a hyaluronan (HA)
receptor) and Vav2 (a guanine nucleotide exchange factor) in human ovarian tumor cells …
receptor) and Vav2 (a guanine nucleotide exchange factor) in human ovarian tumor cells …
Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase
We have previously isolated the hpttg proto-oncogene, which is expressed in normal tissues
containing proliferating cells and in several kinds of tumors. In fact, expression of hPTTG …
containing proliferating cells and in several kinds of tumors. In fact, expression of hPTTG …
Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein
O Sella, G Gerlitz, SY Le… - Molecular and cellular …, 1999 - Am Soc Microbiol
In previous reports we showed that the long 5′ untranslated region (5′ UTR) of c-sis, the
gene encoding the B chain of platelet-derived growth factor, has translational modulating …
gene encoding the B chain of platelet-derived growth factor, has translational modulating …
[HTML][HTML] Vav1 is a component of transcriptionally active complexes
M Houlard, R Arudchandran… - The Journal of …, 2002 - ncbi.nlm.nih.gov
The importance of the hematopoietic protooncogene Vav1 in immune cell function is widely
recognized, although its regulatory mechanisms are not completely understood. Here, we …
recognized, although its regulatory mechanisms are not completely understood. Here, we …
The RNA regulatory programs that govern lymphocyte development and function
MD Diaz‐Muñoz… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Lymphocytes require of constant and dynamic changes in their transcriptome for timely
activation and production of effector molecules to combat external pathogens. Synthesis and …
activation and production of effector molecules to combat external pathogens. Synthesis and …
Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
A Belmonte-Fernández, J Herrero-Ruíz… - Cell Death & …, 2023 - nature.com
Cisplatin and other platinum-based anticancer agents are among the most widely used
chemotherapy drugs in the treatment of different types of cancer. However, it is common to …
chemotherapy drugs in the treatment of different types of cancer. However, it is common to …
Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells
Cell signaling pathways are essentially organized through the distribution of various types of
binding domains in signaling proteins, with each domain binding to specific target …
binding domains in signaling proteins, with each domain binding to specific target …
[HTML][HTML] Ezh2 harnesses the intranuclear actin cytoskeleton to remodel chromatin in differentiating Th cells
M Titelbaum, B Brant, D Baumel, A Burstein-Willensky… - Iscience, 2021 - cell.com
Following their first interaction with the antigen, quiescent naive T-helper (Th; CD4+) cells
enlarge, differentiate, and proliferate; these processes are accompanied by substantial …
enlarge, differentiate, and proliferate; these processes are accompanied by substantial …