Vav1 is a 95‐kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine
phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …

Actin binding proteins (ABPs) have been considered components of the cytoskeleton, which
gives structure and allows mobility of the cell. The complex dynamic properties of the actin …

In this study we initially examined the interaction between CD44v3 (a hyaluronan (HA)
receptor) and Vav2 (a guanine nucleotide exchange factor) in human ovarian tumor cells …

We have previously isolated the hpttg proto-oncogene, which is expressed in normal tissues
containing proliferating cells and in several kinds of tumors. In fact, expression of hPTTG …

In previous reports we showed that the long 5′ untranslated region (5′ UTR) of c-sis, the
gene encoding the B chain of platelet-derived growth factor, has translational modulating …

The importance of the hematopoietic protooncogene Vav1 in immune cell function is widely
recognized, although its regulatory mechanisms are not completely understood. Here, we …

Lymphocytes require of constant and dynamic changes in their transcriptome for timely
activation and production of effector molecules to combat external pathogens. Synthesis and …

Cisplatin and other platinum-based anticancer agents are among the most widely used
chemotherapy drugs in the treatment of different types of cancer. However, it is common to …

Cell signaling pathways are essentially organized through the distribution of various types of
binding domains in signaling proteins, with each domain binding to specific target …

Following their first interaction with the antigen, quiescent naive T-helper (Th; CD4+) cells
enlarge, differentiate, and proliferate; these processes are accompanied by substantial …