Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a
variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In …

In the current research, methaqualone derivatives were synthesized and assessed for their
anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti …

Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including
anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of …

Abstract γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the
mammalian brain and has been found to play an important role in the pathogenesis or the …

Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent
seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts …

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …

The pathophysiological mechanisms underlying epileptogenesis are poorly understood but
are considered to actively involve an imbalance between excitatory and inhibitory synaptic …