Understanding COVID-19-associated coagulopathy

EM Conway, N Mackman, RQ Warren… - Nature Reviews …, 2022 - nature.com
Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

Current and novel biomarkers of thrombotic risk in COVID-19: a consensus statement from the international COVID-19 thrombosis biomarkers colloquium

DA Gorog, RF Storey, PA Gurbel, US Tantry… - Nature Reviews …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and
thromboembolic events, owing to excessive inflammation, endothelial cell activation and …

Precise identification of cell states altered in disease using healthy single-cell references

E Dann, AM Cujba, AJ Oliver, KB Meyer… - Nature Genetics, 2023 - nature.com
Joint analysis of single-cell genomics data from diseased tissues and a healthy reference
can reveal altered cell states. We investigate whether integrated collections of data from …

Vasculopathy in COVID-19

R Flaumenhaft, K Enjyoji… - Blood, The Journal of the …, 2022 - ashpublications.org
COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

Effect of P2Y12 inhibitors on survival free of organ support among non–critically ill hospitalized patients with COVID-19: a randomized clinical trial

JS Berger, LZ Kornblith, MN Gong, HR Reynolds… - Jama, 2022 - jamanetwork.com
Importance Platelets represent a potential therapeutic target for improved clinical outcomes
in patients with COVID-19. Objective To evaluate the benefits and risks of adding a P2Y12 …

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis

Z Tang, Y Xu, Y Tan, H Shi, P Jin, Y Li, J Teng… - Nature …, 2023 - nature.com
Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Increased blood viscosity and red blood cell aggregation in patients with COVID‐19

E Nader, C Nougier, C Boisson… - American journal of …, 2022 - Wiley Online Library
The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability,
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …

Platelets and SARS-CoV-2 during COVID-19: immunity, thrombosis, and beyond

A Sciaudone, H Corkrey, F Humphries… - Circulation …, 2023 - Am Heart Assoc
COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase
mortality in patients. Platelets are fast responders to pathogen presence, alerting the …