Cancer is a complex illness that presents significant challenges in its understanding and
treatment. The classic definition," a group of diseases characterized by the uncontrolled …

Highlights•The current status of nanomedicines and their clinical translation is summarized.•
Challenges to the clinical translation of nanomedicines are summarized.•Strategies and …

Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in
translational oncology, as they share the same environmental risk factors, key histological …

Three-dimensional (3D) bioprinting technologies involving photopolymerizable bioinks
(PBs) have attracted enormous attention in recent times owing to their ability to recreate …

The past decades have witnessed the rapid development and widespread application of
nanomedicines in cancer treatment; however, the clinical translation of experimental …

Immune checkpoint inhibitors (ICI) have been revolutionary in the field of cancer therapy.
However, their success is limited to specific indications and cancer types. Recently, the …

Augmenting adaptive immunity is a critical goal for developing next-generation cancer
therapies. T and B cells infiltrating the tumor dramatically influence cancer progression …

Tumor tissue engineering holds great promise for replicating the physiological and
behavioral characteristics of tumors in vitro. Advances in this field have led to new …

Background: Patient-derived xenograft (PDX) models have been a focus of attention
because they closely resemble the tumor features of patients and retain the molecular and …

Multidrug resistance (MDR) is currently a big challenge in cancer therapy and limits its
success in several patients. Tumors use the MDR mechanisms to colonize the host and …