Simple Summary The desire to reduce the use of animals in research and drug testing has
led to an upsurge in the development of 3-Dimensional models, which try and mimic parts of …

Melanoma, the tumor arising from the malignant transformation of pigment-producing cells—
the melanocytes—represents one of the most severe cancer types. Despite their rarity …

Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly
between patients. To improve therapy efficacy and outcome for cancer patients, more …

Background Globally, breast cancer constitutes the predominant malignancy in women.
Abnormal regulation of epigenetic factors plays a key role in the development of tumors. Anti …

Background: Solanum cernuum Vell.(Solanaceae) is a native plant from Brazil traditionally
used for treating ulcers, liver damage, skin infections, gonorrhea, and benign prostatic …

Head and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year,
More than 830 000 people are diagnosed with HNSCC globally, with more than 430 000 …

Tumor microenvironment has recently been ascribed a new hallmark—the polymorphic
microbiome. Accumulating evidence regarding the tissue specific territories of tumor …

With the increasing incidence and mortality rates, cancer remains a major health challenge
in the world. Despite advances in therapies and clinical programs, the efficacy of anti-cancer …

Statistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid
tumor characterized by high heterogeneity and the presence of a complex extracellular …

Background The chicken chorioallantoic membrane (CAM) model is a potential alternative to
the mouse model based on the 3R principles. However, its value for determination of the in …