The relationship between different dimensions of alcohol use and the burden of disease—an update

J Rehm, GE Gmel Sr, G Gmel, OSM Hasan, S Imtiaz… - …, 2017 - Wiley Online Library
Background and aims Alcohol use is a major contributor to injuries, mortality and the burden
of disease. This review updates knowledge on risk relations between dimensions of alcohol …

Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease

E de Gregorio, A Colell, A Morales, M Marí - International journal of …, 2020 - mdpi.com
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Alcohol use and breast cancer: a critical review

KD Shield, I Soerjomataram… - Alcoholism: Clinical and …, 2016 - Wiley Online Library
The objective of this study was to outline the biological pathways of alcohol‐attributable
breast cancer, the epidemiological risk relationship between alcohol consumption and …

New perspectives on how to formulate alcohol drinking guidelines

K Shield, C Paradis, P Butt, T Naimi, A Sherk… - …, 2024 - Wiley Online Library
Abstract Background Low‐Risk Alcohol Drinking Guidelines (LRDGs) aim to reduce the
harms caused by alcohol. However, considerable discrepancies exist in the 'low …

SIRT1 modulators in experimentally induced liver injury

H Farghali, MK Kemelo… - Oxidative medicine and …, 2019 - Wiley Online Library
This article is directed at highlighting the involvement of the endogenous stress sensor
SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection. The …

Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?

AR Hipkiss, SP Cartwright, C Bromley, SR Gross… - Chemistry Central …, 2013 - Springer
The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on
cellular activity. It delays cellular senescence and rejuvenates cultured senescent …

Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells

J Choupani, S Mansoori Derakhshan… - Journal of cellular …, 2018 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a highly networked cellular process which
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …

Inhibition of tumour cell growth by carnosine: some possible mechanisms

AR Hipkiss, F Gaunitz - Amino Acids, 2014 - Springer
The naturally occurring dipeptide carnosine (β-alanyl-l-histidine) has been shown to inhibit,
selectively, growth of transformed cells mediated, at least in part, by depleting glycolytic ATP …

Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing

PK Prabhakar, K Singh, D Kabra, J Gupta - Phytomedicine, 2020 - Elsevier
Background The occurrence of chronic wounds, account for significant suffering of diabetic
people, together with increasing healthcare burden. The chronic wounds associated with …

[PDF][PDF] D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection

MK Kemelo, L Wojnarova, NK Canová… - Physiological …, 2014 - biomed.cas.cz
Summary D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) is a well known model of
hepatotoxicity that closely resembles acute liver failure (ALF) seen clinically. The role of …