The relationship between different dimensions of alcohol use and the burden of disease—an update
Background and aims Alcohol use is a major contributor to injuries, mortality and the burden
of disease. This review updates knowledge on risk relations between dimensions of alcohol …
of disease. This review updates knowledge on risk relations between dimensions of alcohol …
Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …
Alcohol use and breast cancer: a critical review
KD Shield, I Soerjomataram… - Alcoholism: Clinical and …, 2016 - Wiley Online Library
The objective of this study was to outline the biological pathways of alcohol‐attributable
breast cancer, the epidemiological risk relationship between alcohol consumption and …
breast cancer, the epidemiological risk relationship between alcohol consumption and …
New perspectives on how to formulate alcohol drinking guidelines
Abstract Background Low‐Risk Alcohol Drinking Guidelines (LRDGs) aim to reduce the
harms caused by alcohol. However, considerable discrepancies exist in the 'low …
harms caused by alcohol. However, considerable discrepancies exist in the 'low …
SIRT1 modulators in experimentally induced liver injury
H Farghali, MK Kemelo… - Oxidative medicine and …, 2019 - Wiley Online Library
This article is directed at highlighting the involvement of the endogenous stress sensor
SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection. The …
SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection. The …
Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?
AR Hipkiss, SP Cartwright, C Bromley, SR Gross… - Chemistry Central …, 2013 - Springer
The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on
cellular activity. It delays cellular senescence and rejuvenates cultured senescent …
cellular activity. It delays cellular senescence and rejuvenates cultured senescent …
Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells
J Choupani, S Mansoori Derakhshan… - Journal of cellular …, 2018 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a highly networked cellular process which
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …
Inhibition of tumour cell growth by carnosine: some possible mechanisms
AR Hipkiss, F Gaunitz - Amino Acids, 2014 - Springer
The naturally occurring dipeptide carnosine (β-alanyl-l-histidine) has been shown to inhibit,
selectively, growth of transformed cells mediated, at least in part, by depleting glycolytic ATP …
selectively, growth of transformed cells mediated, at least in part, by depleting glycolytic ATP …
Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing
PK Prabhakar, K Singh, D Kabra, J Gupta - Phytomedicine, 2020 - Elsevier
Background The occurrence of chronic wounds, account for significant suffering of diabetic
people, together with increasing healthcare burden. The chronic wounds associated with …
people, together with increasing healthcare burden. The chronic wounds associated with …
[PDF][PDF] D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection
MK Kemelo, L Wojnarova, NK Canová… - Physiological …, 2014 - biomed.cas.cz
Summary D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) is a well known model of
hepatotoxicity that closely resembles acute liver failure (ALF) seen clinically. The role of …
hepatotoxicity that closely resembles acute liver failure (ALF) seen clinically. The role of …