Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
[HTML][HTML] Challenges of organoid research
MG Andrews, AR Kriegstein - Annual review of neuroscience, 2022 - annualreviews.org
Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …
contain tissue resident cell types and reflect features of early tissue organization. Neural …
Co-transplantation of autologous Treg cells in a cell therapy for Parkinson's disease
The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …
Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
[HTML][HTML] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
H Okano, S Morimoto - Cell Stem Cell, 2022 - cell.com
It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …
technology in 2007, and the scope of its application has been expanding. In addition to the …
[HTML][HTML] Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD
A Kirkeby, J Nelander, DB Hoban, N Rogelius… - Cell Stem Cell, 2023 - cell.com
Cell replacement therapies for Parkinson's disease (PD) based on transplantation of
pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we …
pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we …
[HTML][HTML] Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use
Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …
medicine, including the development of cell replacement paradigms for the treatment of …
[HTML][HTML] In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are
involved in movement control and reward-related cognition. In Parkinson's disease …
involved in movement control and reward-related cognition. In Parkinson's disease …
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
[HTML][HTML] Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease
BM Hiller, DJ Marmion, CA Thompson… - NPJ Regenerative …, 2022 - nature.com
In pursuit of treating Parkinson's disease with cell replacement therapy, differentiated
induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) …
induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) …