Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Since the earliest observations of cells undergoing mitosis, it has been clear that there is an
intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear …

The polyadenosine tail (poly [A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …

Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step
of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of …

Mechanical stimulation of fibroblasts induces changes in the actin cytoskeleton including
stress fiber (SF) reinforcement and realignment. Here we characterize the nuclear response …

Abnormal WNT signaling increases MYC expression in colon cancer cells in part via
oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in …

Transport of macromolecules between the cytoplasm and the nucleus is critical for the
function of all eukaryotic cells. Large macromolecular channels termed nuclear pore …

Vast numbers of proteins are transported into and out of the nuclei by approximately 20
species of importin-β family nucleocytoplasmic transport receptors. However, the …

WNT signaling activates MYC expression in cancer cells. Here we report that this involves
an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear pores to …

A polyA (pA) tail is an essential modification added to the 3′ ends of a wide range of RNAs
at different stages of their metabolism. Here, we describe the main sources of …