Polyamines are small molecules associated with a wide variety of physiological functions.
Bacterial pathogens have developed subtle strategies to exploit polyamines or manipulate …

Pathoadaptive mutations are evolutionary events leading to the silencing of specific anti-
virulence loci. This reshapes the core genome of a novel pathogen, adapts it to the host and …

The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the
evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls …

Infection with Shigella, the organism responsible for the diarrheal disease shigellosis, leads
to approximately 200,000 deaths globally annually. Virulence of this pathogen is primarily …

Enteric pathogens of the family Enterobacteriaceae colonize various niches within animals
and humans in which they compete with intestinal commensals and are attacked by the host …

VirF, an AraC-like activator, is required to trigger a regulatory cascade that initiates the
invasive program of Shigella spp., the etiological agents of bacillary dysentery in humans …

The lifecycle of most microbial pathogens can be divided into two states: existence outside
and inside their hosts. The sudden temperature upshift experienced upon entry from …

Outer membrane protein A (OmpA) is a multifaceted predominant outer membrane protein of
Escherichia coli and other Enterobacteriaceae whose role in the pathogenesis of various …

Shigella spp, the etiological agents of bacillary dysentery in humans, have evolved an
intricate regulatory strategy to ensure fine-tuned expression of virulence genes in response …

ABSTRACT Elongation factor P (EF-P) is a universally conserved bacterial translation factor.
In many bacteria, EF-P is posttranslationally modified by PoxA, which covalently attaches a β …