The evolution of pathogenic bacteria is a multifaceted and complex process, which is
strongly influenced by the horizontal acquisition of genetic elements and their subsequent …

The genomes of Gram-negative bacteria encode paralogues and/or orthologues of global
modulators. The nucleoid-associated H-NS and Hha proteins are an example: several …

Central to bacterial pathogenicity is the precise and coordinated control of virulence gene
expression in response to environmental cues encountered in the human host. This chapter …

Dickeya dadantii is a pathogen infecting a wide range of plant species. Soft rot, the visible
symptom, is mainly due to production of pectate lyases (Pels) that can destroy plant cell …

Shigella spp. cause hundreds of millions of intestinal infections each year. They target the
mucosa of the human colon and are an important model of intracellular bacterial …

AraC family proteins are transcriptional regulators that are defined by the presence of a
conserved DNA binding domain (DBD). My research focused on three AraC family …

Enteropathogenic bacteria, such as Shigella and Salmonella, are associated with diarrheal
diseases, which remain a significant cause of infant mortality worldwide. The secretion of …

Pathogenic bacteria express a myriad of systems aimed at subversion and exploitation of a
host to promote proliferation and survival. Naturally, host cells have evolved equally …

Les bactéries sont confrontées à des environnements fluctuants et doivent adapter leur état
physiologique pour survivre à ces changements. Cette acclimatation passe par une …

ABSTRACT A novel approach to treat the highly virulent and infectious enteric pathogen
Shigella flexneri, with the potential for reduced resistance development, is to target virulence …