Bacteria exist in stressful and constantly changing environments. In order to to sense,
respond to, and survive in various stress conditions, microbes have evolved diverse …

The RhaR and VirF proteins are both members of the large AraC family of bacterial
transcription regulators. RhaR activates expression of the Escherichia coli rhaSR operon in …

The uncontrollable rise in resistance to current antimicrobial agents is a worldwide concern.
Beyond traditional approaches to develop novel antibiotics, targeting bacterial virulence is …

Shigella flexneri causes bacterial dysentery in humans, leading to high rates of morbidity
and mortality each year. While much is known about the invasive process and intracellular …

Small RNAs (sRNAs) are important regulators of gene expression in bacteria, particularly
during stress responses. Many genetically and biochemically well characterized sRNAs …

Ribo-regulators are defined as any RNA molecule that is capable of controlling the
expression of a target gene (s) and/or the activity of a target protein. Ribo-regulators are …

Shigella dysenteriae is a gram-negative enteroinvasive pathogen and a causative agent of
shigellosis, a severe form of dysentery which afflicts over 90 million people annually. The …

Shigella species, the causal agents of bacillary dysentery, use a type III secretion system
(T3SS) to inject two waves of virulence proteins, known as effectors, into the human colonic …

With the advent of industrial biotechnology, we can use microbes to produce myriad
valuable compounds with a range of useful applications. These may be drugs, flavourings …

Understanding molecular mechanisms which regulate bacterial virulence is essential for
discovering new therapeutics. Alarmingly, some bacterial species are already unresponsive …