[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

J Jansen, KC Reimer, JS Nagai, FS Varghese… - Cell stem cell, 2022 - cell.com
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Kidney injury in COVID-19: epidemiology, molecular mechanisms and potential therapeutic targets

JP Teixeira, S Barone, K Zahedi… - International Journal of …, 2022 - mdpi.com
As of December 2021, SARS-CoV-2 had caused over 250 million infections and 5 million
deaths worldwide. Furthermore, despite the development of highly effective vaccines, novel …

Nanosponges: an overlooked promising strategy to combat SARS-CoV-2

E Mostafavi, S Iravani, RS Varma - Drug Discovery Today, 2022 - Elsevier
Highlights•Nanosponges are explored for their antiviral delivery and biological
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …

[HTML][HTML] Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy

LB Argueta, LA Lacko, Y Bram, T Tada, L Carrau… - Iscience, 2022 - cell.com
The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of
placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and …

[HTML][HTML] Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

L Helms, S Marchiano, IB Stanaway, TY Hsiang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?

NP Shakked, MHS de Oliveira, I Cheruiyot, JL Benoit… - Clinical …, 2022 - Elsevier
Abstract Background Coronavirus disease-2019 (COVID-19) is associated with a high risk of
acute kidney injury (AKI), often requiring renal replacement therapy (RRT). Serum Cystatin C …

Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19

N Ray, PH Reddy - Ageing Research Reviews, 2023 - Elsevier
The kidney is an essential organ that removes waste products, balances the body's fluids,
releases hormones that regulate blood pressure, produces an active form of vitamin D …

“Long COVID-19” and viral “fibromyalgia-ness”: Suggesting a mechanistic role for fascial myofibroblasts (Nineveh, the shadow is in the fascia)

S Plaut - Frontiers in Medicine, 2023 - frontiersin.org
The coronavirus pandemic has led to a wave of chronic disease cases;“Long COVID-19” is
recognized as a new medical entity and resembles “fibromyalgia” which, likewise, lacks a …

Kidney in the net of acute and long-haul coronavirus disease 2019: a potential role for lipid mediators in causing renal injury and fibrosis

KC Chiang, JD Imig, K Kalantar-Zadeh… - Current opinion in …, 2022 - journals.lww.com
Summary In COVID-19, the lipid-mediator storm promotes thromboinflammation, ischemia–
reperfusion injury and cytotoxicity. The thromboxane A 2 and PGD 2 signaling presents a …

Atrial fibrillation and clinical outcomes in a cohort of hospitalized patients with SARS-CoV-2 infection and chronic kidney disease

S Genovesi, P Rebora, G Occhino, E Rossi… - Journal of clinical …, 2021 - mdpi.com
The aim of the study was to investigate the role of chronic kidney disease (CKD) on in-
hospital mortality and on incident atrial fibrillation (AF) in patients infected with SARS-CoV-2 …