Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

This selective review discusses the psychobiological mediation of nociception and pain.
Summarizing literature from physiology and neuroscience, first an overview of the …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and
as such, offers a very powerful target for regulation of nociceptive transmission by both local …

In this review, we integrate recent human and animal studies from the viewpoint of chronic
pain. First, we briefly review the impact of chronic pain on society and address current pitfalls …

The idea that pain can lead to feelings of frustration, worry, anxiety and depression seems
obvious, particularly if it is of a chronic nature. However, there is also evidence for the …

A Systems Neuroscience Approach to Migraine: Neuron Skip to Main Content Advertisement
Neuron This journal offers authors two options (open access or subscription) to publish …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

[Frontiers in Bioscience 14, 5291-5338, June 1, 2009] 5291 Neurobiology of depression,
fibromyalgia and neuropathic pain Vladimi Page 1 [Frontiers in Bioscience 14, 5291-5338, June …

A rat population with variable responses to nerve injury indicated that activation of
descending inhibition with a spinal noradrenergic component prevents development of …