Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Neurogenesis is a complex process by which neural progenitor cells (NPCs)/neural stem
cells (NSCs) proliferate and differentiate into new neurons and other brain cells. In …

FIGURE 1. Ketogenesis (simplified). A. When systemic blood glucose levels drop, the low
endogenous carbohydrate levels are unable to sustain the energy requirements of the body …

Several epidemiological studies have clearly identified diabetes mellitus (DM) as a major
risk factor for cognitive dysfunction, and it is going to be a major public health issue in the …

The purpose of this study was to investigate the association between time restricted feeding
(TRF) and different areas of cognitive function in the elderly in Chinese communities. This …

Diet and circadian rhythms have been found to have a profound impact on health, disease,
and aging. Skipping breakfast, eating late, and overeating have adverse effects on the …

Background: The potential positive interaction between intermittent fasting (IF) and brain-
derived neurotrophic factor (BDNF) on cognitive function has been widely discussed. This …

Alzheimer's disease is increasing in prevalence disproportionately to longevity, placing
enormous burden on individuals, families, healthcare systems and the economy …