Obesity and cancer risk: Emerging biological mechanisms and perspectives

KI Avgerinos, N Spyrou, CS Mantzoros, M Dalamaga - Metabolism, 2019 - Elsevier
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …

Obesity and breast cancer: a paradoxical and controversial relationship influenced by menopausal status

L García-Estévez, J Cortés, S Pérez, I Calvo… - Frontiers in …, 2021 - frontiersin.org
Breast cancer is the most common tumor in women worldwide, and an increasing public
health concern. Knowledge of both protective and negative risk factors is essential for a …

[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Obesity and breast cancer: a case of inflamed adipose tissue

R Kolb, W Zhang - Cancers, 2020 - mdpi.com
Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in
postmenopausal women and a worse prognosis for all major breast cancer subtypes …

Adipose tissue, obesity and adiponectin: role in endocrine cancer risk

A Tumminia, F Vinciguerra, M Parisi… - International journal of …, 2019 - mdpi.com
Adipose tissue has been recognized as a complex organ with endocrine and metabolic
roles. The excess of fat mass, as occurs during overweight and obesity states, alters the …

The role of adipokines in breast cancer: current evidence and perspectives

GS Christodoulatos, N Spyrou, J Kadillari… - Current obesity …, 2019 - Springer
Purpose The current review shows evidence for the role of adipokines in breast cancer (BC)
pathogenesis summarizing the mechanisms underlying the association between adipokines …

New horizons: epidemiology of obesity, diabetes mellitus, and cancer prognosis

S Harborg, KA Kjærgaard, RW Thomsen… - The Journal of …, 2024 - academic.oup.com
The global prevalence of obesity and diabetes mellitus has increased in parallel with
increasing cancer incidence, due to environmental and lifestyle factors and population …

Updated clinical evidence on the role of adipokines and breast cancer: a review

GI Verras, L Tchabashvili, DD Chlorogiannis, F Mulita… - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is currently one of the most common types of cancer and the
number one cause of cancer-related deaths in women worldwide. Despite significant …

Multifaceted effects of obesity on cancer immunotherapies: bridging preclinical models and clinical data

LV Vick, RJ Canter, AM Monjazeb… - Seminars in cancer biology, 2023 - Elsevier
Obesity, defined by excessive body fat, is a highly complex condition affecting numerous
physiological processes, such as metabolism, proliferation, and cellular homeostasis. These …

The impact of obesity, adipose tissue, and tumor microenvironment on macrophage polarization and metastasis

O Habanjar, M Diab-Assaf, F Caldefie-Chezet, L Delort - Biology, 2022 - mdpi.com
Simple Summary The inflammatory adipose microenvironment in obesity plays a crucial role
in cancer development and metastases. By focusing on adipocytes and macrophages, as …