[HTML][HTML] Clinical utility of mifepristone: apprising the expanding horizons

ZV Karena, H Shah, H Vaghela, K Chauhan, PK Desai… - Cureus, 2022 - ncbi.nlm.nih.gov
Mifepristone is a progesterone and glucocorticoid receptor antagonist. Medical abortion with
mifepristone and prostaglandin has revolutionized the abortion process extending abortion …

[HTML][HTML] Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways

Y Gan, T Liu, W Feng, L Wang, LI Li, Y Ning - Oncology Research, 2023 - ncbi.nlm.nih.gov
Various therapeutic strategies have been developed to overcome ovarian cancer. However,
the prognoses resulting from these strategies are still unclear. In the present work, we …

Experimental Models for Rare Melanoma Research—The Niche That Needs to Be Addressed

I Ionita, D Malita, C Dehelean, E Olteanu, I Marcovici… - Bioengineering, 2023 - mdpi.com
Melanoma, the tumor arising from the malignant transformation of pigment-producing cells—
the melanocytes—represents one of the most severe cancer types. Despite their rarity …

Disulfiram suppressed peritendinous fibrosis through inhibiting macrophage accumulation and its pro-inflammatory properties in tendon bone healing

Q Zhou, W Wang, F Yang, H Wang, X Zhao… - … in Bioengineering and …, 2022 - frontiersin.org
The communication between macrophages and tendon cells plays a critical role in
regulating the tendon-healing process. However, the potential mechanisms through which …

Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity

GN Landis, L Riggan, HS Bell, W Vu, T Wang… - Frontiers in …, 2022 - frontiersin.org
Mifepristone dramatically increases the life span of mated female Drosophila while reducing
the expression of innate immune response genes. Previous results indicated that …

Alpha-Fetoprotein: A Revolutionary Anti-Cancer Drug

VN Pak - Medical Research Archives, 2023 - esmed.org
Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The
protein serves two critical functions simultaneously: it delivers nutrients to growing embryo …

Survival mechanisms of metastatic melanoma cells: the link between glucocorticoids and the Nrf2-dependent antioxidant defense system

E Obrador, R Salvador-Palmer, R López-Blanch… - Cells, 2023 - mdpi.com
Circulating glucocorticoids increase during stress. Chronic stress, characterized by a
sustained increase in serum levels of cortisol, has been associated in different cases with an …

Liquid biopsy to predict tumor progression in uveal melanoma

P Bustamante Alvarez - 2022 - escholarship.mcgill.ca
Precision oncology is the molecular profiling of a tumor with the ultimate goal to provide an
accurate diagnosis and treatment of cancer patients [5]. To characterize tumor genomes in …

The kinetics and fragmentation of cell-free DNA from cultured cancer cells are influenced by anticancer treatments

P Bustamante, M Abdouh, T Tsering, JV Burnier - 2022 - researchsquare.com
Liquid biopsy-based detection of circulating free DNA (cfDNA) is a promising tool to monitor
tumor progression and treatment response. cfDNA release is thought to result from a …

[图书][B] Liquid Biopsy To Predict Tumor Progression in Uveal Melanoma

PB Alvarez - 2022 - search.proquest.com
Liquid biopsy has emerged as a minimally invasive approach to detect and monitor cancer
progression, recurrence, and response to treatment. Tumor cells release fragments of …