Vaccination continues to be the single most important and successful public health
intervention, due to its prevention of morbidity and mortality from prevalent infectious …

There is an urgent and unmet need to develop effective vaccines to reduce the global
burden of infectious disease in both animals and humans, and in particular for the majority of …

Although there have been no cases of serotype 2 wild poliovirus for more than 20 years,
transmission of serotype 2 vaccine-derived poliovirus (VDPV2) and associated paralytic …

Background Use of oral live-attenuated polio vaccines (OPV), and injected inactivated polio
vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the …

Thirty-one ongoing and new cVDPV type 2 (cVDPV2) outbreaks were documented during
July 2019–February 2020; nine outbreaks spread internationally. New cVDPV2 outbreaks …

Enormous progress has been made in global efforts to eradicate poliovirus, using live-
attenuated Sabin oral poliovirus vaccine (OPV). However, as the incidence of disease due to …

Progress Toward Polio Eradication — Worldwide, January 2017–March 2019 | MMWR Skip
directly to site content Skip directly to page options Skip directly to AZ link Centers for Disease …

Following the synchronized switch from trivalent oral poliovirus vaccine (tOPV, types 1, 2,
and 3) to bivalent oral poliovirus vaccine (bOPV, types 1 and 3 only) in 2016, transmission of …

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-
associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and …

Poliovirus (PV), the virus that causes both acute poliomyelitis and post-polio syndrome, is
classified within the Enterovirus C species, and there are three wild PV serotypes: WPV1 …