Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-
17A, IL-6 and IL-23, in protein and mRNA levels and their correlations with ocular surface …

Validated biomarkers to be used as biological tools for managing ocular surface diseases
(OSDs) are still an unmet need in daily clinical practice. Many studies have contributed to …

Immune-driven dry eye disease primarily affects women; the cause for this sex-specific
prevalence is unknown. Polymorphonuclear neutrophils (PMN) have distinct phenotypes …

Purpose.: To provide standard operating procedures (SOPs) for measuring tear
inflammatory cytokine concentrations and to validate the resulting profile as a minimally …

Objective To determine the effect of desiccating stress on corneal angiogenic responses in
dry eye disease (DED) using a murine model. Methods Dry eye was induced in murine eyes …

The development of long lasting therapeutic agents is critically important for efficient
treatment of chronic diseases. We herein report a rational strategy to develop a therapeutic …

PURPOSE: To evaluate the therapeutic efficacy of topical interleukin-1 receptor antagonist
(IL-1Ra) in the treatment of dry eye disease. DESIGN: Laboratory investigation. METHODS …

Purpose.: To explore the phenomenon that corneal and conjunctival tissues subjected to
desiccating stress (DS) promote Th17 differentiation by stimulating the production of Th17 …

Background Dry eye disease (DED) is a common disease in ophthalmology, affecting
millions of people worldwide. Recent studies have shown that inflammation is the core …