OBJECTIVE: To evaluate the immunomodulatory effect of topical ophthalmic tofacitinib (CP-
690,550) after an 8-week treatment period in patients with dry eye disease (DED). DESIGN …

Abstract Thrombospondin 1 (TSP-1) is an extracellular matrix protein that interacts with a
wide array of ligands including cell receptors, growth factors, cytokines and proteases to …

Objective To determine whether blocking prolymphangiogenic factors such as vascular
endothelial growth factor C (VEGF-C) would suppress alloimmunity in dry eye disease using …

Neuroinflammation plays an important role in the pathogenesis of ocular surface disease,
including dry eye disease (DED), but little is known about the contribution of substance P …

Purpose To enhance the understanding of dry eye (DE) in diabetes by evaluating the ocular
surface characteristics and the levels of tear inflammatory cytokines. Design Cross-sectional …

Purpose.: A majority of experimental data on dry eye disease (DED) immunopathogenesis
have been derived from a murine model of DED that combines desiccating environmental …

Purpose: We investigated the possibility of the nanocomplex of poly (ethylene glycol)(PEG)
and catechin as a new biomedical material to treat dry eye disease. Methods: NOD. B10. H2 …

Topical Fluorometholone Treatment for Ocular Dryness in Pati... : Medicine Topical
Fluorometholone Treatment for Ocular Dryness in Patients With Sjögren Syndrome: A …

Methods.: In this prospective study, based on the ocular surface disease index (OSDI) and
corneal staining (CS), 95 DED patients (OSDI≥ 13) with increasing CS were enrolled into 3 …

Purpose In this study, we examine the expression of corneal epithelium-derived
thrombospondin-1 (TSP-1) and its immunomodulatory functions in a validated murine model …