Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

Globally, colorectal cancer (CRC) is the third most prevalent cancer and the second leading
cause of cancer-related deaths. Circular RNAs (circRNAs) are single-stranded RNA with …

Background Multiple lines of evidence have demonstrated that circular RNAs (circRNAs)
play oncogenic or tumor-suppressive roles in various human cancers. Nevertheless, the …

Abstract Background Cancer stem cells (CSCs) are strongly associated with high
tumourigenicity, chemotherapy or radiotherapy resistance, and metastasis and recurrence …

The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-
associated mortality. However, molecular mechanisms involved in ccRCC metastasis …

Ferroptosis is an iron-dependent regulated form of cell death caused by excessive lipid
peroxidation. This form of cell death differed from known forms of cell death in morphological …

Genome-wide association studies have identified numerous variants associated with human
complex traits, most of which reside in the non-coding regions, but biological mechanisms …

Colorectal cancer (CRC) is one of the most common cancer types, ranking third after lung
and breast cancers. As such, it demands special attention for better characterization, which …