Recent updates on drug resistance in Mycobacterium tuberculosis

R Singh, SP Dwivedi, US Gaharwar… - Journal of applied …, 2020 - academic.oup.com
Tuberculosis (TB) along with acquired immune deficiency syndrome and malaria rank
among the top three fatal infectious diseases which pose threat to global public health …

Drug resistant Tuberculosis: A review

JL Khawbung, D Nath, S Chakraborty - … immunology, microbiology and …, 2021 - Elsevier
Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming
counter attack of TB worldwide. However, when it was known that TB can be cured …

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care

N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

[HTML][HTML] New agents for the treatment of drug-resistant Mycobacterium tuberculosis

DT Hoagland, J Liu, RB Lee, RE Lee - Advanced drug delivery reviews, 2016 - Elsevier
Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction

ARM Coates, Y Hu, J Holt, P Yeh - Expert review of Anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …

Bacterial enzymes and antibiotic resistance

AM Egorov, MM Ulyashova… - Acta Naturae …, 2018 - cyberleninka.ru
The resistance of microorganisms to antibiotics has been developing for more than 2 billion
years and is widely distributed among various representatives of the microbiological world …

A fast and agnostic method for bacterial genome-wide association studies: Bridging the gap between k-mers and genetic events

M Jaillard, L Lima, M Tournoud, P Mahé… - PLoS …, 2018 - journals.plos.org
Genome-wide association study (GWAS) methods applied to bacterial genomes have
shown promising results for genetic marker discovery or detailed assessment of marker …

The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

NJE Waller, CY Cheung, GM Cook… - Nature …, 2023 - nature.com
The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

The changing paradigm of drug-resistant tuberculosis treatment: successes, pitfalls, and future perspectives

N Dookie, SL Ngema, R Perumal… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …