Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Fluorescent probes capable of precise detection of atherosclerosis (AS) at an early stage
and fast assessment of anti‐AS drugs in animal level are particularly valuable. Herein, a …

Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …

Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular
tone and a complex series of cellular and molecular events termed 'vascular remodelling' …

Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary
pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β …

Abstract Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular
matrix (ECM), which serve a significant role in the pathological processes of various …

Hypoxia, defined as a reduced oxygen availability, can be observed in many tissues in
response to various physiological and pathological conditions. As a hallmark of the altitude …

Background: TSP1 (thrombospondin-1)—a well-known angiogenesis inhibitor—mediates
differential effects via interacting with cell surface receptors including CD36 (cluster of …

Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling
of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a …