The role of miRNAs in insulin resistance and diabetic macrovascular complications–A review

SSA Mageed, AS Doghish, A Ismail… - International journal of …, 2023 - Elsevier
Diabetes is the most prevalent metabolic disturbance disease and has been regarded
globally as one of the principal causes of mortality. Diabetes is accompanied by several …

Tirzepatide, a new era of dual-targeted treatment for diabetes and obesity: a mini-review

VP Chavda, J Ajabiya, D Teli, J Bojarska… - Molecules, 2022 - mdpi.com
The prevalence of obesity and diabetes is an increasing global problem, especially in
developed countries, and is referred to as the twin epidemics. As such, advanced treatment …

Dietary polyphenols as natural inhibitors of α-amylase and α-glucosidase

I Ćorković, D Gašo-Sokač, A Pichler, J Šimunović… - Life, 2022 - mdpi.com
It is well known that carbohydrates are the main source of calories in most diets. However,
by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved. α …

A review on the green synthesis of benzimidazole derivatives and their pharmacological activities

M Nardi, NCH Cano, S Simeonov, R Bence, A Kurutos… - Catalysts, 2023 - mdpi.com
Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic
agents, eg, antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of …

Self‐Powered Syringe Pump for Insulin Pump Therapy Based on High‐Voltage Triboelectric Nanogenerator and Dielectric Elastomer Actuator

Y Wei, W Wu, Y Wang, X Chen… - Advanced Functional …, 2023 - Wiley Online Library
Insulin pump therapy (IPT) is commonly utilized for treating type 1 diabetes. However, the
insulin pump is generally rigid, and its prolonged use can cause discomfort to patients …

Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies

M Kaur, S Mishra, P Swarnkar, P Patel, BD Kurmi… - Biochemical …, 2023 - Elsevier
Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …

Polymeric micelles loaded with glyburide and vanillic acid: I. Formulation development, in-vitro characterization and bioavailability studies

J Kaur, M Gulati, P Famta, L Corrie, A Awasthi… - International Journal of …, 2022 - Elsevier
The co-formulation of glyburide (Gly) and vanillic acid (VA) as such in the form of
nanomedicine has never been explored to treat metabolic diseases including type 2 …

Polyphenols-rich polyherbal mixture attenuates hepatorenal impairment, dyslipidaemia, oxidative stress and inflammation in alloxan-induced diabetic rats

B Aslam, A Hussain, ZUD Sindhu, S Nigar… - Journal of Applied …, 2023 - Taylor & Francis
Effects of polyherbal mixture on hepatorenal injury and dyslipidaemia in alloxan-induced
diabetic rats were evaluated. Alloxan monohydrate (120 mg/kg, ip) was injected into Wistar …

Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational …

M Devi, P Kumar, R Singh, J Sindhu… - European Journal of …, 2023 - Elsevier
In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …

Brazilin: biological activities and therapeutic potential in chronic degenerative diseases and cancer

DA Nava-Tapia, L Cayetano-Salazar… - Pharmacological …, 2022 - Elsevier
Caesalpinia sappan and Haematoxylum brasiletto belong to the Fabaceae family,
predominantly distributed in Southeast Asia and America. The isoflavonoid brazilin has …