The emergence and spread of antimicrobial-resistant bacterial, viral, and fungal pathogens
for which diminishing treatment options are available is of major global concern. New viral …

Exposure of the adaptive immune system to a pathogen can result in the activation and
expansion of T cells capable of recognizing not only the specific antigen but also different …

Introduction Significant evidence suggests a connection between transplant rejection and
the presence of high levels of pre-existing memory T cells. Viral infection can elicit viral …

We hypothesized that HIV-specific CD8 T cell clonotypes can be stimulated by allogeneic
HLA molecules. Multiple HIV-specific CD8 T cell clones were derived from 12 individuals …

Background Antibodies directed against HLA can develop through pregnancy, blood
transfusions, or organ transplants. Anecdotal evidence suggests that virus-specific …

Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a
clonal level. However, the impact of a single virus on the allorepertoire has never been …

Background HLA-A29-positive birdshot chorioretinitis (BCR) is an inflammatory eye disorder
that is generally assumed to be caused by an autoimmune response to HLA-A29-presented …

Background and Objectives Allogeneic hematopoietic stem cell transplantation (HSCT) is a
routine clinical procedure performed to treat patients with haematological malignancies …

Background HLA-A29-positive birdshot chorioretinitis (BCR) is an inflammatory eye disorder
that is generally assumed to be caused by an autoimmune response to HLA-A29-presented …

A goal of cancer immunologists is to harness cellular immune responses to achieve anti-
cancer responses. One of the strongest activating stimuli for the immune system is the …