Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
L Gao, Y Zhang, K Sterling, W Song - Translational Neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …
arise as the disease progresses. A growing body of evidence suggests that pathological …
The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
BDNF as a promising therapeutic agent in Parkinson's disease
E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …
A path toward precision medicine for neuroinflammatory mechanisms in Alzheimer's disease
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …
represents one of the earliest pathomechanistic alterations throughout the AD continuum …
[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people
X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …
seriously threatens the quality of patients' life, especially the older people. Accumulating …
The role of BDNF in the neuroimmune axis regulation of mood disorders
Y Jin, LH Sun, W Yang, RJ Cui, SB Xu - Frontiers in neurology, 2019 - frontiersin.org
The neuroimmune system plays a crucial role in the regulation of mood disorders. Moreover,
recent studies show that brain-derived neurotrophic factor (BDNF), a member of the …
recent studies show that brain-derived neurotrophic factor (BDNF), a member of the …
Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …
Unfolding the Role of BDNF as a Biomarker for Treatment of Depression
T Rana, T Behl, A Sehgal, P Srivastava… - Journal of Molecular …, 2021 - Springer
Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …
interest in activities, and decreased energy. The symptoms of depression are usually …
How does exercise reduce the rate of age-associated cognitive decline? A review of potential mechanisms
G Kennedy, RJ Hardman… - Journal of …, 2017 - content.iospress.com
The rate of age-associated cognitive decline varies considerably between individuals. It is
important, both on a societal and individual level, to investigate factors that underlie these …
important, both on a societal and individual level, to investigate factors that underlie these …
Higher brain BDNF gene expression is associated with slower cognitive decline in older adults
Objectives: We tested whether brain-derived neurotrophic factor (BDNF) gene expression
levels are associated with cognitive decline in older adults. Methods: Five hundred thirty-five …
levels are associated with cognitive decline in older adults. Methods: Five hundred thirty-five …