From street to lab: in vitro hepatotoxicity of buphedrone, butylone and 3, 4-DMMC

R Roque Bravo, H Carmo, MJ Valente, JP Silva… - Archives of …, 2021 - Springer
Synthetic cathinones are among the most popular new psychoactive substances, being
abused for their stimulant properties, which are similar to those of amphetamine and 3, 4 …

S-(+)-Pentedrone and R-(+)-methylone as the most oxidative and cytotoxic enantiomers to dopaminergic SH-SY5Y cells: Role of MRP1 and P-gp in cathinones …

B Silva, A Palmeira, R Silva, C Fernandes… - Toxicology and Applied …, 2021 - Elsevier
Cathinone derivatives are the most representative group within new drugs market, which
have been described as neurotoxic. Since cathinones, as pentedrone and methylone, are …

Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay

LHJ Richter, A Beck, V Flockerzi, HH Maurer… - Toxicology Letters, 2019 - Elsevier
New psychoactive substances (NPS) are still an emerging issue in clinical and forensic
toxicology. Information about their cytotoxic potential is limited or even unavailable before …

Can NMR spectroscopy discriminate between NPS amphetamines and cathinones? An evaluation by in silico studies and chemometrics

CHP Rodrigues, VBP Leite, AT Bruni - Chemometrics and Intelligent …, 2021 - Elsevier
The use of new psychoactive substances (NPS) has become a problem that affects many
countries. Because new chemical structures appear frequently and reliable reference data …

Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells

B Silva, JS Rodrigues, AS Almeida, AR Lima… - Pharmaceuticals, 2022 - mdpi.com
Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic
processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated …

Evaluation of long‐term detection trends of new psychoactive substances in pooled urine from city street portable urinals (London, UK)

JRH Archer, F Mendes, S Hudson… - British Journal of …, 2020 - Wiley Online Library
Aims To evaluate the long‐term trends of new psychoactive substance (NPS) detection in
pooled urine samples collected across a city centre. Methods Pooled urine samples from …

Reporting two fatalities associated with the use of 4-methylethcathinone (4-MEC) and a review of the literature

PR Smith, R Cole, S Hamilton, K West… - Journal of Analytical …, 2016 - academic.oup.com
We report two fatalities that are related to the cathinone 4-methylethcathinone (4-MEC) and
review the current knowledge of 4-MEC. Qualitative and quantitative analysis of 4-MEC was …

An approach to the new psychoactive drugs phenomenon

H Dolengevich-Segal, B Rodríguez-Salgado… - Salud …, 2017 - medigraphic.com
Background. The new psychoactive drugs (NPD) are those that represent a danger to public
health and are not prohibited by conventions on international narcotics. The concept also …

Structure assignment of seized products containing cathinone derivatives using high resolution analytical techniques

JL Gonçalves, VL Alves, J Aguiar, MJ Caldeira… - Metabolites, 2021 - mdpi.com
The innovation of the new psychoactive substances (NPS) market requires the rapid
identification of new substances that can be a risk to public health, in order to reduce the …

Rapid detection of synthetic cannabinoid receptor agonists impregnated into paper by attenuated total reflectance Fourier transform infrared spectroscopy

T Coombs, A Abdelkader, L Tang… - Journal of Forensic …, 2023 - Wiley Online Library
The last few years have witnessed the change in the modalities of smuggling of synthetic
cannabinoid receptor agonists (SCRAs) by impregnating them in mail envelopes and fast …