[HTML][HTML] The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
mRNA-based cancer therapeutics
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …
treatments in a shorter time frame and with reduced expense compared to conventional …
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease
D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
A Barmada, J Klein, A Ramaswamy, NN Brodsky… - Science …, 2023 - science.org
Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …
[HTML][HTML] Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
[HTML][HTML] Nanotechnology-based strategies against SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …
[HTML][HTML] Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
[HTML][HTML] COVID-19 mRNA vaccines: Platforms and current developments
GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …
COVID-19, myocarditis and pericarditis
DL Fairweather, DJ Beetler, DN Di Florio… - Circulation …, 2023 - Am Heart Assoc
Viral infections are a leading cause of myocarditis and pericarditis worldwide, conditions that
frequently coexist. Myocarditis and pericarditis were some of the early comorbidities …
frequently coexist. Myocarditis and pericarditis were some of the early comorbidities …