mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV
L Matarazzo, PJG Bettencourt - Frontiers in Immunology, 2023 - frontiersin.org
The success of the first licensed mRNA-based vaccines against COVID-19 has created a
widespread interest on mRNA technology for vaccinology. As expected, the number of …
widespread interest on mRNA technology for vaccinology. As expected, the number of …
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases
D Bhattacharya - Immunity, 2022 - cell.com
Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …
decades of viral immunology research, ultimately leading to the crowning achievement of …
mRNA vaccine development for emerging animal and zoonotic diseases
T Le, C Sun, J Chang, G Zhang, X Yin - Viruses, 2022 - mdpi.com
In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise
because of their low risk of insertional mutagenesis, high potency, accelerated development …
because of their low risk of insertional mutagenesis, high potency, accelerated development …
The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system
MC Bernard, E Bazin, N Petiot, K Lemdani… - … Therapy-Nucleic Acids, 2023 - cell.com
The use of modified nucleosides is an important approach to mitigate the intrinsic
immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA …
immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA …
[HTML][HTML] A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery
A Gerhardt, E Voigt, M Archer, S Reed, E Larson… - … Therapy Methods & …, 2022 - cell.com
Current RNA vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) are limited by instability of both the RNA and the lipid nanoparticle delivery system …
CoV-2) are limited by instability of both the RNA and the lipid nanoparticle delivery system …
Innate immune mechanisms of mRNA vaccines
The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity
D Lapuente, TH Winkler, M Tenbusch - Cellular & Molecular …, 2024 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
prompted scientific, medical, and biotech communities to investigate infection-and vaccine …
prompted scientific, medical, and biotech communities to investigate infection-and vaccine …
mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model
C Sittplangkoon, MG Alameh, D Weissman… - Frontiers in …, 2022 - frontiersin.org
An mRNA with unmodified nucleosides induces type I interferons (IFN-I) through the
stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for …
stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for …
An ionizable lipid material with a vitamin E scaffold as an mRNA vaccine platform for efficient cytotoxic T cell responses
R Oyama, H Ishigame, H Tanaka, N Tateshita… - ACS …, 2023 - ACS Publications
RNA vaccines based on lipid nanoparticles (LNPs) with in vitro transcribed mRNA (IVT-
mRNA) encapsulated are now a currently successful but still evolving modality of vaccines …
mRNA) encapsulated are now a currently successful but still evolving modality of vaccines …
Delivery and expression of mRNA in the secondary lymphoid organs drive immune responses to lipid nanoparticle-mRNA vaccines after intramuscular injection
A Takanashi, CW Pouton, H Al-Wassiti - Molecular Pharmaceutics, 2023 - ACS Publications
Lipid nanoparticles (LNPs) are the prime delivery vehicle for mRNA vaccines. Previous
hypotheses suggested that LNPs contribute to innate reactogenicity and lead to the …
hypotheses suggested that LNPs contribute to innate reactogenicity and lead to the …