Emerging Molecular and Synaptic Targets for the Management of Chronic Pain Caused by Systemic Lupus Erythematosus
HR Weng - International Journal of Molecular Sciences, 2024 - mdpi.com
Patients with systemic lupus erythematosus (SLE) frequently experience chronic pain due to
the limited effectiveness and safety profiles of current analgesics. Understanding the …
the limited effectiveness and safety profiles of current analgesics. Understanding the …
New Insight into Neuropathic Pain: The Relationship between α7nAChR, Ferroptosis, and Neuroinflammation
F Luo, C Huang - International Journal of Molecular Sciences, 2024 - mdpi.com
Neuropathic pain, which refers to pain caused by a lesion or disease of the somatosensory
system, represents a wide variety of peripheral or central disorders. Treating neuropathic …
system, represents a wide variety of peripheral or central disorders. Treating neuropathic …
Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice
H Hasriadi, PWD Wasana, W Thongphichai… - Scientific Reports, 2024 - nature.com
Alkaloid analgesics have been associated with adverse effects on the central nervous
system (CNS). Therefore, it is crucial to characterize the effects of alkaloid analgesics. Plants …
system (CNS). Therefore, it is crucial to characterize the effects of alkaloid analgesics. Plants …
Molecular Aspects Involved in the Mechanisms of Bothrops jararaca Venom-Induced Hyperalgesia: Participation of NK1 Receptor and Glial Cells
AOP Bom, M Dias-Soares, RCD Corrêa, CL Neves… - Toxins, 2024 - mdpi.com
Accidents caused by Bothrops jararaca (Bj) snakes result in several local and systemic
manifestations, with pain being a fundamental characteristic. The inflammatory process …
manifestations, with pain being a fundamental characteristic. The inflammatory process …
Can we use biomarkers to identify those at risk of acute pain from sickle cell disease?
V Bhat, VA Sheehan - Expert Review of Hematology, 2024 - Taylor & Francis
Introduction Acute pain episodes, also known as vaso-occlusive crises (VOC), are a major
symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of …
symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of …
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway
F Nan, Q Tian, S Chen - Drug Design, Development and Therapy, 2024 - Taylor & Francis
Background Treating inflammatory pain (IP) continues to pose clinical challenge, because of
the lack of effective pharmacological interventions. Microglial polarization serves as pivotal …
the lack of effective pharmacological interventions. Microglial polarization serves as pivotal …
Mitigating Secondary Conditions of Injury and Disease; the Dichotomy of Soluble and Transmembrane Tumor Necrosis Factor
T Martynyuk - 2024 - search.proquest.com
Spinal cord injury (SCI) is a devastating condition which negatively impacts an individual's
immune system. The spleen is a major immune organ, and its innervation is disrupted after …
immune system. The spleen is a major immune organ, and its innervation is disrupted after …