Overweight and obesity have reached epidemic levels in the United States and worldwide,
and this has contributed to substantial cardiovascular and other health risks. However …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Obesity is worldwide epidemic given its rapid growth in global prevalence. Among the risk
factors contributing to obesity, human gut microbiome recently emerges with unprecedented …

Abstract Background Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor,
has been extensively demonstrated to be associated with metabolic disorders, including …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

The melanocortin 4 receptor (MC4R) plays a critical role in the long-term regulation of
energy homeostasis, and mutations in the MC4R are the most common cause of monogenic …

Abstract Purpose of Review This review aims to present current information on genes
underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and …

Importance More than one-third of the adult population in the United States is obese. Obesity
has been linked to factors such as genetics, diet, physical activity, and the environment …

Mendelian randomization (MR) has been used to estimate the causal effect of body mass
index (BMI) on particular traits thought to be affected by BMI. However, BMI may also be a …