Many contemporary and past articles dealing with the fibromyalgia syndrome (FMS) have
indicated that its pathogenesis is unknown. That statement is no longer correct and should …

Transient receptor potential vanilloid 1 (TRPV1) receptor is a nonselective cation channel
activated by capsaicin, a pungent substance from chili peppers. It is considered to act as an …

Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared
by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and …

The cloned vanilloid receptor VR1 can be activated by capsaicin and by thermal stimuli. The
pattern of nerve terminals that contain VR1 in adult rat spinal cord does not correspond to …

Hybrid compounds (also known as chimeras, designed multiple ligands, bivalent
compounds) are chemical units where two active components, usually possessing affinity …

Previous work has indicated that the dermis and epidermis of skin contains abundant nerve
fibres closely associated with Langerhans' cells. We have investigated whether these nerve …

Nerve fibers project into the bone marrow and terminate in association with stromal cells.
Nerve terminals are also associated with antigen‐processing and‐presenting cells …

Noradrenaline‐and peptide‐containing nerve fibres project into the bone marrow and
terminate in association with stromal cells and within the parenchyma. Peptidergic nerve …

Previous and current research has revealed that most neuropeptides induce their actions on
cellular systems through specific receptors located on the cell surface. These receptors are …

Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-
terminal metabolites appear to play a role in the development of antinociception. Because …