Lineage relationships among the large number of heterogeneous cell types generated
during development are difficult to reconstruct in a high-throughput manner. We recently …

Cell lineages provide the framework for understanding how cell fates are decided during
development. Describing cell lineages in most organisms is challenging; even a fruit fly larva …

The cellular signalling process is a highly complex mechanism, involving multiple players,
which together orchestrate the cell's response to environmental changes and perturbations …

During tumor evolution, cancer cells can acquire the ability to proliferate, invade neighboring
tissues, evade the immune system, and spread systemically. Tracking this process remains …

Complex 3D tissues arise during development following tightly organized events in space
and time. In particular, gene regulatory networks and local interactions between single cells …

DNA has not been utilized to record temporal information, although DNA has been used to
record biological information and to compute mathematical problems. Here, we found that …

The dynamics of genetic diversity in large clonally evolving cell populations are poorly
understood, despite having implications for the treatment of cancer and microbial infections …

Genomic DNA barcoding has emerged as a sensitive and flexible tool to measure the fates
of clonal subpopulations within a heterogeneous cancer cell population. Coupling cellular …

Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits
to enhance phenotype-based drug discovery, to map the molecular origins of disease, and …

CRISPR-Cas9-based genome editing combined with single-cell sequencing enables the
tracing of the history of cell divisions, or cellular lineage, in tissues and whole organisms …