Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

Abstract The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) …

Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global
pathogen with limited treatment options. No new antibiotic chemical class with activity …

Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …

Antimicrobial resistance (AMR) is a critical issue in health care in terms of mortality, quality of
services, and financial damage. In the battle against AMR, it is crucial to recognize the …

Background Cefiderocol is a last resort option for carbapenem-resistant (CR) Gram-negative
bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has
become a significant public health problem globally. The management of this issue using …

Carbapenem resistance in Gram-negative bacteria has come into sight as a serious global
threat. Carbapenem-resistant Gram-negative pathogens and their main representatives …

The discovery of antibiotics has revolutionized medicine and has changed medical practice,
enabling successful fighting of infection. However, quickly after the start of the antibiotic era …