Osteosarcoma is the most common primary bone tumour in children and adolescents and
advanced osteosarcoma patients with evidence of metastasis share a poor prognosis …

Tumor cells leave the primary tumor and enter the circulation. Once there, they are called
circulating tumor cells (CTC s). A fraction of CTC s are capable of entering distant sites and …

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

Oncogenic events combined with a favourable environment are the two main factors in the
oncological process. The tumour microenvironment is composed of a complex …

Disseminated prostate cancer (PCa) cells in the marrow survive for years without evidence
of proliferation, while maintaining the capacity to develop into metastatic lesions. These …

Metastases are the major cause of cancer patients' mortality and can occur years and even
decades following apparently successful treatment of the primary tumor. Early dissemination …

Cancer recurrence remains a great fear for many cancer survivors following their initial,
apparently successful, therapy. Despite significant improvement in the overall survival of …

Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types.
PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition …

Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …