Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

DNA repair processes are critical to maintaining genomic integrity. As a result, dysregulation
of repair genes is likely to be linked with health implications, such as an increased …

Infertility is a globally recognized issue caused by different reproductive disorders. To date,
various therapeutic approaches to restore fertility have been attempted including etiology …

Aims This study aimed to explore the effect of epididymosomes on the proliferative efficiency
of spermatogonial stem cells (SSCs) in vitro and the resumption of spermatogenesis in the …

An increasing number of men require long-term drug therapy for various diseases. However,
the effects of long-term drug therapy on male fertility are often not well evaluated in clinical …

Infertility has become one of the most common issues worldwide, which has negatively
affected society and infertile couples. Meanwhile, male infertility is responsible for about …

Background: In vitro induction of spermatogonial stem cells (SSCs) from embryonic stem
cells (ESCs) provides a promising tool for the treatment of male infertility. A variety of …

Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids,
mRNAs, and miRNAs between living cells. Their role in cellular communication has gained …

Spermatogonial stem cells (SSCs) are capable of transmitting genetic information to the next
generations and they are the initial cells for spermatogenesis. Nevertheless, it remains …