N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an
important role in learning and memory, and are critical for spatial memory. These receptors …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

The contribution of the NMDA receptors (NMDARs) to synaptic plasticity declines during
aging, and the decline is thought to contribute to memory deficits. Here, we demonstrate that …

N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral
cortex and hippocampus and play an important role in learning and memory. NMDA …

Calcium (Ca2+) is a highly versatile intracellular signaling molecule that is essential for
regulating a variety of cellular and physiological processes ranging from fertilization to …

The NMDA receptor plays a critical role in the development of the central nervous system
and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this …

Subunit composition of N-methyl-d-aspartate–type glutamate receptors (NMDARs) dictates
their function, yet the ontogenic profiles of human NMDAR subunits from gestation to …

Aging in the biological system is an irreversible process. In the initial stages of lifespan
aging improves survival skills of an organism while in the later stages aging reduce the …

More than 20 years have passed since the discovery that NMDAR-mediated synaptic activity
is important for the functional development of sensory brain circuits1 by specifically …

Glutamate signaling is essential for the persistent neural activity in prefrontal cortex (PFC)
that enables working memory. Metabotropic glutamate receptors (mGluRs) are a diverse …