Highlights•AlphaFold models have rigid protein structures.•Advanced deep algorithms fed
relevant data can accurately predict structures.•Algorithmic advances can harness …

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that target
GABAA receptors (GABAARs) to tune inhibitory synaptic signaling throughout the central …

Abstract γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in
the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of …

Type A γ-aminobutyric acid receptors (GABAARs) are the principal inhibitory receptors in the
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …

The predominant inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA), acts at
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …

The selective interaction of nanomaterials with proteins for protein function suppression has
been reported. However, whether the nanomaterials could be used to target a three …

Parasitic flatworms cause various clinical and veterinary infections that impart a huge
burden worldwide. The most clinically impactful infection is schistosomiasis, a neglected …

Abstract α5 subunit-containing γ-aminobutyric acid type A (GABAA) receptors represent a
promising drug target for neurological and neuropsychiatric disorders. Altered expression …

Methaqualone, a quinazolinone marketed commercially as Quaalude, is a central nervous
system depressant that was used clinically as a sedative-hypnotic, then became a notorious …

We report that diazepam binding inhibitor (DBI) is a glial messenger mediating satellite glia-
sensory neuron crosstalk in the dorsal root ganglion (DRG). DBI is highly expressed in …