Navigating the complex landscape of benzodiazepine-and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond
F Koniuszewski, FD Vogel, I Dajić, T Seidel… - Frontiers in …, 2023 - frontiersin.org
Introduction Medications which target benzodiazepine (BZD) binding sites of GABAA
receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry …
receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry …
Factors promoting the release of picrotoxin from the trap in the GABA (A) receptor pore
JV Bukanova, EI Solntseva, VG Skrebitsky - Neurochemistry International, 2024 - Elsevier
Picrotoxin (PTX), a convulsant of plant origin, has been used in many studies as research
tool. PTX is the open channel blocker of the GABA A receptor (GABA AR). Being in the pore …
tool. PTX is the open channel blocker of the GABA A receptor (GABA AR). Being in the pore …
Unraveling the Mechanisms of Cannabidiol's Pharmacological Actions: A Comprehensive Research Overview
I Kalsoom, K Shehzadi, H Li, H Wen, M Yu - Topics in Current Chemistry, 2024 - Springer
Cannabis sativa has long been used for neurological and psychological healing. Recently,
cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical …
cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical …
Epileptic Encephalopathy GABRB Structural Variants Share Common Gating and Trafficking Defects
CC Hernandez, N Hu, W Shen, RL Macdonald - Biomolecules, 2023 - mdpi.com
Variants in the GABRB gene, which encodes the β subunit of the GABAA receptor, have
been implicated in various epileptic encephalopathies and related neurodevelopmental …
been implicated in various epileptic encephalopathies and related neurodevelopmental …
Structure-function Studies of GABA (A) Receptors and Related computer-aided Studies
FH Mohamad, MA Mohamad Jamali… - Journal of Molecular …, 2023 - Springer
The γ-aminobutyric acid type A receptor (GABA (A) receptor) is a membrane protein
activated by the neurotransmitter GABA. Structurally, this major inhibitory neurotransmitter …
activated by the neurotransmitter GABA. Structurally, this major inhibitory neurotransmitter …
Elucidating the binding mechanisms of GABA and Muscimol as an avenue to discover novel GABA-mimetic small molecules
AR Issahaku, A Wilhelm, M Schutte-Smith… - Journal of …, 2024 - Taylor & Francis
Gamma-aminobutyric acid (GABA) signaling is the principal inhibitory pathway in the central
nervous system. It is critical in neuronal cell proliferation and fate determination. Any …
nervous system. It is critical in neuronal cell proliferation and fate determination. Any …
Integrated workflow for the identification of new GABAAR positive allosteric modulators based on the in silico screening with further in vitro validation. Case study …
M Platonov, O Maximyuk, A Rayevsky… - Molecular …, 2024 - Wiley Online Library
Numerous studies reported an association between GABAAR subunit genes and epilepsy,
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
Investigating catalytic pathways: a comparative review of homogeneous and heterogeneous catalysis for 3-aroylimidazo [1, 2-a] pyridine synthesis
M Moutaouakil, O Roby, S Tighadouini, A Cherif… - Molecular Diversity, 2023 - Springer
aroylimidazo [1, 2-a] pyridines represent a class of derivatives in the imidazo [1, 2-a] pyridine
family known for their important biological and pharmaceutical activities. Consequently …
family known for their important biological and pharmaceutical activities. Consequently …
Molecular modelling reveals how abundance of α4 sub-type in synaptic GABARA receptor can lead to refractoriness toward GABA and BZ-type drugs
T Chaudhuri, MV Hosur - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Epilepsy is a complex neurological disorder with genetic and acquired causes, and the
drugs presently used to treat epilepsy are not effective in about 30% of the cases …
drugs presently used to treat epilepsy are not effective in about 30% of the cases …
Synthesis of Selenium-Based Small Molecules Inspired by CNS-Targeting Psychotropic Drugs and Mediators
Due to its endogenously high oxygen consumption, the central nervous system (CNS) is
vulnerable to oxidative stress conditions. Notably, the activity of several CNS-targeting …
vulnerable to oxidative stress conditions. Notably, the activity of several CNS-targeting …