Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Background Clinical trials and real-world studies revealed a spectrum of response to CGRP
(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at …

Calcitonin gene-related peptide-targeted monoclonal antibodies (CGRP mAbs) are
increasingly being used as preventive treatments for migraine. Their effectiveness and …

Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …

The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …

Background This study investigated the mechanism of action of atogepant, a small-molecule
CGRP receptor antagonist recently approved for the preventive treatment of episodic …

Recently, we showed that while atogepant-a small-molecule calcitonin gene-related peptide
(CGRP) receptor antagonist-does not fully prevent activation of nociceptors, it significantly …

BACKGROUND The trigeminal nerve directly innervates key vascular structures both
centrally and peripherally. Centrally, it is known to innervate the brainstem and cavernous …

Migraine is a complex neurological disorder characterized by headache and sensory
abnormalities, such as hypersensitivity to light, observed as photophobia. Whilst it is …