Cell senescence is defined as a state of irreversible cell cycle arrest combined with DNA
damage and the induction of a senescence-associated secretory phenotype (SASP). This …

Cellular senescence, a state of irreversible growth arrest triggered by various stressors,
engages in a category of pathological processes, whereby senescent cells accumulate in …

Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic
inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and …

Over the past 20 years, various identifiers of cellular senescence have been used to quantify
the abundance of these cells in different tissues. These include classic markers such as p16 …

Senescence is a condition of cell cycle arrest that increases inflammation and contributes to
the development of chronic diseases in the aging human body. While several compounds …

Background: Stem cell aging, characterized by elevated p16 INK4a expression, decreases
cell repopulating and self-renewal abilities, which results in elevated inflammation and slow …

Background Skeletal muscle has extraordinary regenerative capabilities against challenge,
mainly owing to its resident muscle stem cells, commonly identified by Pax7+, which …

Abstract p16 INK4a expression is a robust biomarker of senescence for stem cells in human
tissues. Here we examined the effect of exercise intensity on in vivo senescence in skeletal …

Cellular senescence has become a subject of great interest within the ageing research field
over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul …

Extracellular vesicles (EVs) can be released from most cells in the body and act as
intercellular messengers transferring information in their cargo to affect cellular function. A …