Mutations of coding regions and splice sites of SLC26A4 cause Pendred syndrome and
nonsyndromic recessive hearing loss DFNB4. SLC26A4 encodes pendrin, a …

The stria vascularis (SV) has been shown to play a critical role in the pathogenesis of many
diseases associated with sensorineural hearing loss (SNHL), including age-related hearing …

The NLRP3 inflammasome is an intracellular innate immune sensor that is expressed in
immune cells, including monocytes and macrophages. Activation of the NLRP3 …

The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is
necessary for proper hair cell mechanotransduction and hearing. While channels belonging …

Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting
communication and quality of life for millions of older adults. Multiple pathophysiologic …

The stria vascularis (SV) in the cochlea generates and maintains the endocochlear potential,
thereby playing a pivotal role in normal hearing. Knowing transcriptional profiles and gene …

Sensorineural hearing loss can result from dysfunction of the inner ear, auditory nerve, or
auditory pathways in the central nervous system. Sensorineural hearing loss can be …

Tissue-resident macrophages play an important role in clearance, development, and
regulation of metabolism. They also function as sentinel immune cells, initiating …

In mammals, sperm cells produced within the testis are structurally differentiated but remain
immotile and are unable to fertilize the oocyte unless they undergo a series of maturation …

Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in
humans, afflicting one in every thousand newborns. The majority is of heritable origin and …