[HTML][HTML] Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

A Okuzumi, T Hatano, G Matsumoto, S Nojiri, S Ueno… - Nature medicine, 2023 - nature.com
Abnormal α-synuclein aggregation is a key pathological feature of a group of
neurodegenerative diseases known as synucleinopathies, which include Parkinson's …

[HTML][HTML] Fluid and biopsy based biomarkers in Parkinson's disease

DG Coughlin, DJ Irwin - Neurotherapeutics, 2023 - Elsevier
Several advances in fluid and tissue-based biomarkers for use in Parkinson's disease (PD)
and other synucleinopathies have been made in the last several years. While work …

[HTML][HTML] Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis

J Huang, Y Cheng, C Li, H Shang - Translational Neurodegeneration, 2022 - Springer
A growing amount of evidence has indicated contributions of variants in causative genes of
Parkinson's disease (PD) to the development of sleep disturbance in PD and prodromal PD …

[HTML][HTML] Alpha-synuclein in peripheral tissues as a possible marker for neurological diseases and other medical conditions

FJ Jiménez-Jiménez, H Alonso-Navarro… - Biomolecules, 2023 - mdpi.com
The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues
(blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological …

Diagnosis and treatment of essential tremor

AW Shukla - CONTINUUM: Lifelong Learning in Neurology, 2022 - journals.lww.com
PURPOSE OF REVIEW Essential tremor is a chronic, progressive syndrome that primarily
presents with an action tremor involving the arms and hands. This article reviews the history …

[HTML][HTML] Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease

H Peng, S Chen, S Wu, X Shi, J Ma, H Yang… - Journal of the …, 2023 - Elsevier
Abstract Parkinson's disease (PD), the most common neurological motor system disorder,
which characterised by the irreversible loss of dopaminergic neurones in the substantia …

[HTML][HTML] Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes

Y Han, D Wu, Y Wang, J Xie, Z Zhang - EBioMedicine, 2022 - thelancet.com
Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by
the formation of Lewy bodies comprised mainly of α-synuclein. Assessment of skin synuclein …

Peripheral cutaneous synucleinopathy characteristics in genetic Parkinson's disease

Y Yuan, Y Wang, M Liu, H Luo, X Liu, L Li… - Frontiers in …, 2024 - frontiersin.org
Background Cutaneous phosphorylated alpha-synuclein (p-α-syn) deposition is an
important biomarker of idiopathic Parkinson's disease (iPD). Recent studies have reported …

The Molecular Impact of Glucosylceramidase Beta 1 (Gba1) in Parkinson's Disease: a New Genetic State of the Art

JCC Dos Santos, GBC Mano… - Molecular …, 2024 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder affecting 2–3% of those aged
over 65, characterized by motor symptoms like slow movement, tremors, and muscle rigidity …

Unraveling Autonomic Dysfunction in GBA‐Related Parkinson's Disease

G Devigili, G Straccia, E Cereda… - Movement Disorders …, 2023 - Wiley Online Library
ABSTRACT Background Patients with Parkinson's disease (PD) and GBA gene mutations
(GBA‐PD) develop nonmotor complications more frequently than noncarriers. However, an …