Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

SI Van De Wakker, FM Meijers, JPG Sluijter… - Pharmacological …, 2023 - ASPET
Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

[HTML][HTML] Recent advances in regenerative medicine strategies for cancer treatment

V Mansouri, N Beheshtizadeh, M Gharibshahian… - Biomedicine & …, 2021 - Elsevier
Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

Advances and perspectives in dental pulp stem cell based neuroregeneration therapies

J Luzuriaga, Y Polo, O Pastor-Alonso… - International journal of …, 2021 - mdpi.com
Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for
regenerative therapies given their ability to grow in the absence of serum and their realistic …

Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine

A Basu, VK Tiwari - Clinical Epigenetics, 2021 - Springer
Epigenetic mechanisms are known to define cell-type identity and function. Hence,
reprogramming of one cell type into another essentially requires a rewiring of the underlying …

Distinctive clinical and pathologic features of immature teratomas arising from induced pluripotent stem cell-derived beta cell injection in a diabetes patient

L Han, H He, Y Yang, Q Meng, F Ye… - Stem cells and …, 2022 - liebertpub.com
Induced pluripotent stem cells (iPSCs) are a new potential cure for diabetes, characterized
by a capacity for self-renewal and differentiation to pancreatic islet beta cells, which secrete …

Promises and challenges of cell-based therapies to promote lung regeneration in idiopathic pulmonary fibrosis

A Egea-Zorrilla, L Vera, B Saez, A Pardo-Saganta - Cells, 2022 - mdpi.com
The lung epithelium is constantly exposed to harmful agents present in the air that we
breathe making it highly susceptible to damage. However, in instances of injury to the lung, it …

Stem cell therapy for acute myocardial infarction: Mesenchymal Stem Cells and induced Pluripotent Stem Cells

D Clavellina, W Balkan, JM Hare - Expert opinion on biological …, 2023 - Taylor & Francis
Introduction Acute myocardial infarction (AMI) remains a leading cause of death in the
United States. The limited capacity of cardiomyocytes to regenerate and the restricted …

[HTML][HTML] A risk-based approach for cell line development, manufacturing and characterization of genetically engineered, induced pluripotent stem cell–derived …

JL Dashnau, Q Xue, M Nelson, E Law, L Cao, D Hei - Cytotherapy, 2023 - Elsevier
Advances in cellular reprogramming and gene-editing approaches have opened up the
potential for a new class of ex vivo cell therapies based on genetically engineered, induced …

Cellular therapeutic potential of genetically engineered stem cells in cancer treatment

EK Sher, A Kalić, A Džidić-Krivić, MB Zećo… - Biotechnology and …, 2023 - Taylor & Francis
Traditional therapeutic approaches in the treatment of cancer have many side effects and
are often ineffective and non-specific, leading to the development of therapy-resistant …