ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease

PO Katz, KB Dunbar, FH Schnoll-Sussman… - Official journal of the …, 2022 - journals.lww.com
Gastroesophageal reflux disease (GERD) continues to be among the most common
diseases seen by gastroenterologists, surgeons, and primary care physicians. Our …

Evaluation and management of laryngopharyngeal reflux disease: state of the art review

JR Lechien, LM Akst, AL Hamdan… - … –Head and Neck …, 2019 - journals.sagepub.com
Objective To review the current literature about the epidemiology, clinical presentation,
diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed …

Laryngopharyngeal reflux and voice disorders: a multifactorial model of etiology and pathophysiology

JR Lechien, S Saussez, B Harmegnies, C Finck… - Journal of voice, 2017 - Elsevier
Objective The aim of this paper is to shed light on the pathogenesis and pathophysiological
mechanisms underlying the development of hoarseness related to laryngopharyngeal reflux …

Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets

Y Li, G Xu, B Zhou, Y Tang, X Liu, Y Wu… - European Archives of …, 2022 - Springer
Purpose Laryngopharyngeal reflux disease (LPRD) is a general term for the reflux of
gastroduodenal contents into the laryngopharynx, oropharynx and even the nasopharynx …

Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018

JR Lechien, S Saussez, PD Karkos - Current opinion in …, 2018 - journals.lww.com
Diagnosis remains controversial despite improvement in impedance and availability of
pepsin detection in daily practice. With recent studies exhibiting a significant prevalence of …

Pepsin and oropharyngeal pH monitoring to diagnose patients with laryngopharyngeal reflux

M Weitzendorfer, SA Antoniou, P Schredl… - The …, 2020 - Wiley Online Library
Objectives The aim of this study was to compare the diagnostic accuracy of salivary pepsin
with oropharyngeal pH monitoring using the Restech measurement system (Dx‐pH) for the …

Is pepsin a reliable marker of laryngopharyngeal reflux? A systematic review

C Calvo-Henríquez, A Ruano-Ravina… - … –Head and Neck …, 2017 - journals.sagepub.com
Objective Laryngopharyngeal reflux (LPR) is a common illness of otolaryngology visits. Over
the past few years, pepsin has become a promising marker of LPR. The objective of the …

Laryngopharyngeal reflux: a state-of-the-art algorithm management for primary care physicians

JR Lechien, S Saussez, V Muls, MR Barillari… - Journal of clinical …, 2020 - mdpi.com
Laryngopharyngeal reflux (LPR) is a common disease in the general population with acute
or chronic symptoms. LPR is often misdiagnosed in primary care because of the lack of …

Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis

J Wang, Y Zhao, J Ren, Y Xu - European Archives of Oto-Rhino …, 2018 - Springer
Objective Pepsin in saliva has been proposed as a biomarker for the diagnosis of
laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the …

Correlation of salivary and nasal lavage pepsin with MII‐pH testing

MJ Klimara, N Johnston, TL Samuels… - The …, 2020 - Wiley Online Library
Objectives Laryngopharyngeal reflux (LPR) is a common upper airway disease. Salivary
pepsin is a proposed marker for LPR; however, the optimal time for collection of specimens …