PURPOSE: To analyze the available data concerning mechanisms of action of and
mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more …

Tubulin binding agents constitute an important class of antimitotics and are widely used for
the treatment of solid tumours an haematopoietic malignancies. These compounds, currently …

The purpose of this study was to evaluate the antitumor activity of vinorelbine and oral
estramustine phosphate in patients with metastatic, hormone-refractory prostate cancer. We …

A vinblastine resistant cell line, KCVB2, was established by co-selecting the parental
erythroleukemic cell line K562 with step-wise increased concentrations of vinblastine …

Non-small cell lung cancer (NSCLC) is refractory to systemic chemotherapy, compared with
small cell lung cancer. Until recently, only five drugs—cisplatin, vindesine, mitomycin …

Abstract Paclitaxel (Taxol) and vinorelbine (Navelbine) are both microtubule toxins but with
opposite mechanisms of action, Paclitaxel promotes the assembly of microtubules, whereas …

Non‐small cell lung cancer (NSCLC) accounts for about 80% of all primary lung cancers,
and 60% of cases present as advanced stages IIIB and IV disease. Traditionally, treatment of …

Objective. To review the role of chemotherapy in advanced non-small-cell lung cancer,
focusing on cisplatin-based regimens and two new drugs: paclitaxel and gemcitabine. Data …

Introduction Vinorelbine alone and irinotecan alone have been shown to have efficacy
against non-small cell lung cancer (NSCLC); each drug has different mechanisms of action …

Adynamic ileus in a patient with non-small-cell lung cancer after treatment with vinorelbine. -
Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About …