Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …

[HTML][HTML] The role of mitochondria in amyotrophic lateral sclerosis

EF Smith, PJ Shaw, KJ De Vos - Neuroscience letters, 2019 - Elsevier
Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases

Y Zhang, H Yang, D Wei, X Zhang, J Wang, X Wu… - …, 2021 - Wiley Online Library
Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis

J Zhao, X Wang, Z Huo, Y Chen, J Liu, Z Zhao, F Meng… - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats

RK Yadav, S Mehan, R Sahu, S Kumar… - Human & …, 2022 - journals.sagepub.com
Methylmercury (MeHg) is a neurotoxin that induces neurotoxicity and cell death in neurons.
MeHg increases oligodendrocyte death, glial cell activation, and motor neuron …

[HTML][HTML] Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

SK Jha, NK Jha, D Kumar, RK Ambasta… - Biochimica et Biophysica …, 2017 - Elsevier
Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …

A robust TDP-43 knock-in mouse model of ALS

SL Huang, LS Wu, M Lee, CW Chang… - Acta neuropathologica …, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor
neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral …

[HTML][HTML] Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis

GY Wang, SL Rayner, R Chung, BY Shi, XJ Liang - Materials Today Bio, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a
progressive neurodegenerative disease that affects both upper and lower motor neurons …

HIV-associated motor neuron disease: HERV-K activation and response to antiretroviral therapy

LN Bowen, R Tyagi, W Li, T Alfahad, B Smith, M Wright… - Neurology, 2016 - AAN Enterprises
Objective: To determine whether there is activation of human endogenous retrovirus K
(HERV-K) in amyotrophic lateral sclerosis in HIV infection and whether it might respond to …

Among Gerontogens, heavy metals are a class of their own: A review of the evidence for cellular senescence

ST Vielee, JP Wise Jr - Brain Sciences, 2023 - mdpi.com
Advancements in modern medicine have improved the quality of life across the globe and
increased the average lifespan of our population by multiple decades. Current estimates …