Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Background Circadian rhythms are important for all aspects of biology; virtually every aspect
of biological function varies according to time of day. Although this is well known, variation …

In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …

Cardiac fibroblasts are the major producers of extracellular matrix (ECM) to form infarct scar.
We hypothesized that fibroblasts undergo a spectrum of phenotype states over the course of …

In response to myocardial infarction (MI), neutrophils (PMNs) are early responders that
initiate the inflammatory reaction. Because macrophages and fibroblasts show polarization …

Context Vascular aging, including endothelial dysfunction secondary to oxidative stress and
inflammation, increases the risk for age-associated cardiovascular disease (CVD). Low …

Cardiac fibrosis has been known to play an important role in the etiology of heart failure after
myocardial infarction (MI). B lymphoma Mo-MLV insertion region 1 homolog (BMI1), a …

Introduction Macrophages and neutrophils are primary leukocytes involved in the
inflammatory response to myocardial infarction (MI). While interleukin (IL)-4 is an in vitro anti …

The functional relevance of right atrial (RA) function in pulmonary hypertension (PH)
remains incompletely understood. The purpose of this study was to explore the correlation of …

Previous studies have demonstrated an inverse relation between resting muscle
sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (ie, sympathetic …