Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …

Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in
mammalian cells. The current understanding of PDC regulation involves inhibitory serine …

Abstract Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target
mitochondrial proteins for lysine deacetylation and also regulate cellular functions. And …

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or
deacylase activity and are linked to various cancer-related biological pathways as regulators …

Sirtuins are NAD+‐dependent protein deacylases that cleave off acetyl, as well as other acyl
groups, from the ε‐amino group of lysines in histones and other substrate proteins. Seven …

Cancer metabolism is an extensively studied field since the discovery of the Warburg effect
about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancer due
to its highly aggressive phenotype and lack of effective biomarkers or treatment strategies …