High serum concentrations of IL-1β and IL-18 are correlated to malignancies with low-rate
survival from time of diagnosis. The multimeric complex of the inflammasome is responsible …

미토콘드리아는 세포 에너지 공급을 위한 에너지 대사의 주요 세포 소기관으로 칼슘 조절, 활성
산소 (ROS) 생성, 세포 사멸 (apoptosis) 을 조절하는데도 중요한 역할을 한다. 이러한 …

U osnovi kancerogeneze nalazi se akumulacija različitih genetičkih i epigentičkih promena.
Epigenetički mehanizmi (metilacija DNK, modifikacija histona i nekodirajuće RNK) regulišu …

Cancer is one of the most feared diseases in our modern society and many resources are
spent on developing new ways of diagnosis, prevention and treatment. Luckily for us, our …

Sirtuins build a family of NAD+-dependent histone and protein deacetylases that are
involved in a variety of cellular processes including proliferation, metabolism, genomic …

Epigenetic modulations are represented by changes of the function of a genome without
changing the sequence of nucleotides. Besides methylation of DNA, epigenetic modulation …

As we age and across various types of disease, levels of the molecule NAD+(nicotinamide
adenine dinucleotide) decline. Derived from different sources including vitamin B3, NAD+ is …

Epithelial ovarian cancer (EOC) is highly metastatic with late-onset symptoms, making it the
leading cause of death in women with gynecologic malignancies. The proposed mechanism …